Catching Fire: Candida albicans, Macrophages, and Pyroptosis
نویسندگان
چکیده
1 Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, 2 Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, 3 Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America, 4 Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America, 5 Veterans Affairs Medical Center, Iowa City, Iowa, United States of America
منابع مشابه
Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.
Pyroptosis is an inflammasome-mediated programmed cell death pathway triggered in macrophages by a variety of stimuli, including intracellular bacterial pathogens. Activation of pyroptosis leads to the secretion of interleukin-1β (IL-1β) and pore-mediated cell lysis. Although not considered an intracellular pathogen, Candida albicans is able to kill and, thereby, escape from macrophages. Here, ...
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The fungal pathogen Candida albicans causes macrophage death and escapes, but the molecular mechanisms remained unknown. Here we used live-cell imaging to monitor the interaction of C. albicans with macrophages and show that C. albicans kills macrophages in two temporally and mechanistically distinct phases. Early upon phagocytosis, C. albicans triggers pyroptosis, a proinflammatory macrophage ...
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